The model also enters Week 5 of the 2021 season on an incredible 124-82 run on top-rated NFL picks that dates back to the 2017 season. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six-plus years ago. Is the game one of the Week 5 NFL Vegas odds you should bet on? Can the 49ers pull off a much-needed upset? All of the NFL lines are listed below, and before making any Week 5 NFL picks on these games or others, be sure to see the Week 5 NFL predictions from the proven computer model at SportsLine. Can you trust the Niners to cover one of the larger NFL spreads of the week? The 49ers have lost their last two games and will now start rookie quarterback Trey Lance. They are five-point favorites in the latest Week 5 NFL odds at Caesars Sportsbook. The Cardinals are coming off their best win of the young season, beating the Rams by 17 points on the road last week. Arizona can strengthen its grip on the NFC West standings and remain undefeated when it hosts San Francisco on Sunday as part of the Week 5 NFL schedule.
